This chapter discusses the synthesis and functionalization of polymeric matrices with smart or stimuli-sensitive polymers by gamma-rays. These smart components were reviewed from their preparation, properties and potential applications. The performance of these materials as drug delivery systems provide specific characteristics for the design of novel polymers with enormous chances in biotechnology applications. Specifically, the use of gamma radiation for the synthesis of graft copolymers and modification of hydrogels using pH and thermo sensitive monomers, are discussed in this chapter. The effects of the absorbed dose, monomer concentration and reaction time on the amount of graft, are also mentioned. Poly(N-isopropylacrylamide) (PNIPAAm) and poly(acrylic acid) (PAAc) are some of the most popular stimuli-sensitive polymers that have been grafted onto different polymeric matrices. PNIPAAm is thermo-sensitive material which undergoes a phase transition (LCST) of about 32 °C, in aqueous media. On the other hand, PAAc is pH sensitive polymer which has a capability to undergo further chemical reaction to produce new functional groups. As an example, a combination of these products can play an important role as medical device or delivery systems for the local release of drugs for curative or prophylactic purposes. Currently, intense research is being carried out to design medical devices with improved features regarding biocompatibility and therapeutic performance.
Authors
Muñoz-Muñoz, Franklin
Contreras-García, Angel
Burillo, Guillermina
Bucio, Emilio
Keywords
Rayos-gamma,
Polímeros inteligentes,
Liberación de fármacos,
Dispositivos médicos,
IPNs,
Hidrogeles,
Gamma-rays,
Smart polymers,
Drug delivery,
Medical devices,
Hydrogels
